Millions of people worldwide suffer from DED as it is one of the most prevalent ocular disorders the prevalence of DED in China has been estimated to be over 30%. Introductionĭry eye disease (DED), a type of multifactorial disease accompanied by various ocular symptoms, is mainly caused by the instability of the tear film and the imbalance of the microenvironment of the ocular surface, which could accompany the inflammation and damage of the ocular surface and neurosensory disorders, which is according to the consensus of DED in China (2020). The measurements of the SMTube may provide a novel, swift, noninvasive, and convenient approach to screen and diagnose DED with acceptable repeatability and reproducibility and specific correlations with TMH, BUT, and SIT. The Spearman rank correlation coefficients between SMTube and TMH SMTube and Schirmer I test and SMTube and BUT were 0.632, 0.617, and 0.653, respectively (all ). ![]() The SMTube measurements had correlations with TMH, BUT, and SIT. The ICCs between the repeatability and reproducibility of the SMTube measurements were 0.789 and 0.741, respectively, and the Bland–Altman 95% limits of the repeatability and the reproducibility were −1.726 to 1.658 and −0.967 to 1.474, respectively (all ). The repeatability and reproducibility of the SMTube measurements were good in DED patients. The repeatability and reproducibility of the measurements were assessed by the intraclass correlation coefficient (ICC) and the Bland–Altman analysis, and the correlations were evaluated by the Spearman rank-order correlation. Every subject was subjected to the following five measurements sequentially: the Ocular Surface Disease Index (OSDI) questionnaire, Tear Meniscus Height (TMH) assessment, SMTube measurements, tear film breakup time (BUT) examination, and Schirmer I test (SIT). ![]() The study recruited 73 eyes of 49 DED patients. To evaluate the intraobserver repeatability and interobserver reproducibility of Strip Meniscometry Tube (SMTube) and determine the correlations among the SMTube measurements and other ocular examinations in dry eye disease (DED) patients.
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